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Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Strategic Study of CAE 1999, Volume 1, Issue 2, Pages 87-90

Abstract: from Chinese herbal medicine has proved to be one of the most effective ways for the development of newThis paper describes the progress in creating new drugs based on researches on natural products chemistryfor many years and some interesting new trends emerging from recent literature.It should be emphasized that the investigation of bioactive compounds for creating new drugs is the majorAn intimate combination of basic study and drug development should be accomplished under a well-warrantee

Keywords： natural product research creating new drug chemical constituent of Chinese herbal medicine modem spectroscopic

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new categoryWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, weThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given withcurative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively

Keywords： cancer drug resistance genetic screens senescence targeted therapy

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Creating a new university-education system to promote Agriculture Green Development

Fusuo ZHANG, Weichun DONG, Jianqiang LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 1, Pages 114-116 doi: 10.15302/J-FASE-2019319

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Analysis on Methods of Forming the Ideas of Creating a Completely New Product

Shi Aifen,Xie Jianhua

Strategic Study of CAE 2002, Volume 4, Issue 11, Pages 89-93

Abstract: consumers, this article focuses on the study of the flowchart and the technique of forming the ideas of creatinga completely new product.idea of inventing a flying machine as an example, it explores the internal law of forming the ideas of creatinga completely new product.Finally, adjust, perfect and evaluate it and get the set of ideas of creating a completely new product

Keywords： the complete new product the idea matter-element the implicative nature of matter-element

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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1, Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: It involves new drug research and development, innovation of traditional Chinese medicineTo promote the new drug research and development based on integrative pharmacy, the design idea of integrative,and a new drug development system should be established for integrative drugs.It is a new pharmacy theory and practice system that can promote human health and improve the existing

Keywords： integrative pharmacy integrative drugs new drug development drug evaluation clinical medication guidance

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonarydrug delivery (PDD).leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering improved pressure aqueous technique

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussedFinally, future prospects of developing new and better semi-solid excipients are discussed with the objective

Keywords： controlled release drug delivery semi-solids polymer excipient

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3, Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite hollow spheres synthesis drug release

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Concepts for the Construction of a New National Drug Service System

Wang Jian,Yuan Chunping,Wang Hao,Zhang Zhirong,Zhang Qiang,Chen Guiliang,Liu Changxiao,Hou Huimin and Yang Shengli

Strategic Study of CAE 2017, Volume 19, Issue 2, Pages 62-67 doi: 10.15302/J-SSCAE-2017.02.010

Abstract:

Although the current drug service system can meet the fundamental needsspecialist consultation, and a panel discussion, this study investigated the current status of the drugWe propose an idea for constructing a new national drug service system to provide drugs to the Chinese

Keywords： drug service system pharmaceutical industry supervision development strategy

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance antifolates molecular markers Plasmodium vivax China

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Creating Smart Waterworks to Produce Healthy Drinking Water

Li’an Hou

Engineering 2019, Volume 5, Issue 5, Pages 826-827 doi: 10.1016/j.eng.2019.07.017

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Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesEach was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effectsThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyThe clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:

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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4, Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Keywords： bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch